6-(Tetrazol-5-yl)-7-aminoazolo[1,5-a]pyrimidines as Novel Potent CK2 Inhibitors

In this work, we describe the design, synthesis, and structure-activity relationship of 6-(tetrazol-5-yl)-7-aminoazolo[1,5-a]pyrimidines as inhibitors of Casein kinase 2 (CK2). At first, we optimized the reaction conditions for the azide-nitrile cycloaddition in the series of 6-cyano-7-aminoazolopyr...

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Detalles Bibliográficos
Autores principales: Urakov, Grigoriy V., Savateev, Konstantin V., Kotovskaya, Svetlana K., Rusinov, Vladimir L., Spasov, Alexandr A., Babkov, Denis A., Sokolova, Elena V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783892/
https://www.ncbi.nlm.nih.gov/pubmed/36557833
http://dx.doi.org/10.3390/molecules27248697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783892/
https://www.ncbi.nlm.nih.gov/pubmed/36557833
http://dx.doi.org/10.3390/molecules27248697

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