Olaparib Conjugates with Selenopheno[3,2-c]quinolinone Inhibit PARP1 and Reverse ABCB1-Related Multidrug Resistance

The restoration of the efficacy of antitumor medicines is a cornerstone in the combat with multidrug resistant (MDR) cancers. The overexpression of the ABCB1 transporter is a major obstacle to conventional doxorubicin therapy. The synergy of ABCB1 suppression and PARP1 activity inhibition that hampe...

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Detalles Bibliográficos
Autores principales: Makrecka-Kuka, Marina, Vasiljeva, Jelena, Dimitrijevs, Pavels, Arsenyan, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783898/
https://www.ncbi.nlm.nih.gov/pubmed/36559065
http://dx.doi.org/10.3390/pharmaceutics14122571

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9783898/
https://www.ncbi.nlm.nih.gov/pubmed/36559065
http://dx.doi.org/10.3390/pharmaceutics14122571

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