DNA Nanoflowers’ Amelioration of Lupus Symptoms in Mice via Blockade of TLR7/9’s Signal

Inhibitory oligodeoxynucleotides (INH-ODN) can exert an immunomodulatory effect to specifically block TLR7 and TLR9 signaling in systemic lupus erythematosus (SLE). To extend the half-life of INH-ODN in vivo, the phosphorothioate backbone, instead of the native phosphodiester, is preferred due to it...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Gan, Mingzhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784230/
https://www.ncbi.nlm.nih.gov/pubmed/36555668
http://dx.doi.org/10.3390/ijms232416030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784230/
https://www.ncbi.nlm.nih.gov/pubmed/36555668
http://dx.doi.org/10.3390/ijms232416030

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