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Impact of Early Intrapatient Variability of Tacrolimus Concentrations on the Risk of Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation Using High-Dose Post-Transplant Cyclophosphamide

Tacrolimus (Tac) is a pivotal immunosuppressant agent used to prevent graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (alloHSCT). Tac is characterized by a narrow therapeutic window and a high inter-patient and intra-patient pharmacokinetic variability (IPV). Although hig...

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Detalles Bibliográficos
Autores principales: Marco, Daniel N., Salas, María Queralt, Gutiérrez-García, Gonzalo, Monge, Inés, Riu, Gisela, Carcelero, Esther, Roma, Joan Ramón, Llobet, Noemí, Arcarons, Jordi, Suárez-Lledó, María, Martínez, Nuria, Pedraza, Alexandra, Domenech, Ariadna, Rosiñol, Laura, Fernández-Avilés, Francesc, Urbano-Ispízua, Álvaro, Rovira, Montserrat, Brunet, Mercè, Martínez, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784628/
https://www.ncbi.nlm.nih.gov/pubmed/36558980
http://dx.doi.org/10.3390/ph15121529