Decreased Hyocholic Acid and Lysophosphatidylcholine Induce Elevated Blood Glucose in a Transgenic Porcine Model of Metabolic Disease

(1) Background: This work aims to investigate the metabolomic changes in PIGinH11 pigs and investigate differential compounds as potential therapeutic targets for metabolic diseases. (2) Methods: PIGinH11 pigs were established with a CRISPR/Cas9 system. PNPLA3(I148M), hIAPP, and GIPR(dn) were knocke...

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Detalles Bibliográficos
Autores principales: Xu, Jianping, Zhang, Kaiyi, Qiu, Bintao, Liu, Jieying, Liu, Xiaoyu, Yang, Shulin, Xiao, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784658/
https://www.ncbi.nlm.nih.gov/pubmed/36557202
http://dx.doi.org/10.3390/metabo12121164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784658/
https://www.ncbi.nlm.nih.gov/pubmed/36557202
http://dx.doi.org/10.3390/metabo12121164

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