Torsemide Pharmacometrics in Healthy Adult Populations Including CYP2C9 Genetic Polymorphisms and Various Patient Groups through Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling

Torsemide is a widely used diuretic in clinical practice. In this study, pharmacokinetic (PK) and pharmacodynamic (PD) simulations of torsemide for various population groups and exposure scenarios were performed through human-scale physiologically-based PK-PD (PBPK-PD) modeling of torsemide. For PBP...

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Detalles Bibliográficos
Autores principales: Jeong, Seung-Hyun, Jang, Ji-Hun, Lee, Yong-Bok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784843/
https://www.ncbi.nlm.nih.gov/pubmed/36559213
http://dx.doi.org/10.3390/pharmaceutics14122720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784843/
https://www.ncbi.nlm.nih.gov/pubmed/36559213
http://dx.doi.org/10.3390/pharmaceutics14122720

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