Antiviral Activity and Crystal Structures of HIV-1 gp120 Antagonists

As part of our effort to discover drugs that target HIV-1 entry, we report the antiviral activity and crystal structures of two novel inhibitors in a complex with a gp120 core. NBD-14204 showed similar antiviral activity against all the clinical isolates tested. The IC(50) values were in the range o...

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Detalles Bibliográficos
Autores principales: Curreli, Francesca, Kwon, Young D., Nicolau, Isabella, Burgos, Giancarla, Altieri, Andrea, Kurkin, Alexander V., Verardi, Raffaello, Kwong, Peter D., Debnath, Asim K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784924/
https://www.ncbi.nlm.nih.gov/pubmed/36555641
http://dx.doi.org/10.3390/ijms232415999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784924/
https://www.ncbi.nlm.nih.gov/pubmed/36555641
http://dx.doi.org/10.3390/ijms232415999

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