Targeting a Conserved Lysine in the Hydrophobic Pocket of HIV-1 gp41 Improves Small Molecule Antiviral Activity

Human Immunodeficiency virus (HIV-1) fusion is mediated by glycoprotein-41, a protein that has not been widely exploited as a drug target. Small molecules directed at the gp41 ectodomain have proved to be poorly drug-like, having moderate efficacy, high hydrophobicity and/or high molecular weight. W...

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Detalles Bibliográficos
Autores principales: He, Li, Zhou, Guangyan, Sofiyev, Vladimir, Garcia, Eddie, Nguyen, Newton, Li, Kathy H., Gochin, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784957/
https://www.ncbi.nlm.nih.gov/pubmed/36560708
http://dx.doi.org/10.3390/v14122703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784957/
https://www.ncbi.nlm.nih.gov/pubmed/36560708
http://dx.doi.org/10.3390/v14122703

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