An In Vitro Model to Investigate the Potential of Solid Dispersions to Form Pharmacobezoars

The formation of pharmacobezoars from suspensions of spray-dried amorphous solid dispersions (SD-ASDs) of new chemical entities (NCEs) and hydroxypropyl methylcellulose acetate succinate (HPMC-AS) represents a non-compound related adverse effect in preclinical oral toxicity studies in rodents. Where...

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Detalles Bibliográficos
Autores principales: Gierke, Hannes, Schaefer, Kerstin, Gerlich, Lukas, Willmann, Ann-Cathrin, Bialetzki, Verena, Boeck, Georg, Pfrommer, Teresa, Nolte, Thomas, Weitschies, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785156/
https://www.ncbi.nlm.nih.gov/pubmed/36559103
http://dx.doi.org/10.3390/pharmaceutics14122608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785156/
https://www.ncbi.nlm.nih.gov/pubmed/36559103
http://dx.doi.org/10.3390/pharmaceutics14122608

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