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An In Vitro Model to Investigate the Potential of Solid Dispersions to Form Pharmacobezoars

The formation of pharmacobezoars from suspensions of spray-dried amorphous solid dispersions (SD-ASDs) of new chemical entities (NCEs) and hydroxypropyl methylcellulose acetate succinate (HPMC-AS) represents a non-compound related adverse effect in preclinical oral toxicity studies in rodents. Where...

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Detalles Bibliográficos
Autores principales:	Gierke, Hannes, Schaefer, Kerstin, Gerlich, Lukas, Willmann, Ann-Cathrin, Bialetzki, Verena, Boeck, Georg, Pfrommer, Teresa, Nolte, Thomas, Weitschies, Werner
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785156/ https://www.ncbi.nlm.nih.gov/pubmed/36559103 http://dx.doi.org/10.3390/pharmaceutics14122608

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