Synthesis and Pharmacological Evaluation of Enantiopure N-Substituted Ortho-c Oxide-Bridged 5-Phenylmorphans

The design of enantiopure stereoisomers of N-2-phenylcyclopropylmethyl-substituted ortho-c oxide-bridged phenylmorphans, the E and Z isomers of an N-cinnamyl moiety, and N-propyl enantiomers were based on combining the most potent oxide-bridged phenylmorphan (the ortho-c isomer) with the most potent...

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Detalles Bibliográficos
Autores principales: Li, Fuying, Kopajtic, Theresa A., Katz, Jonathan L., Luo, Dan, Prisinzano, Thomas E., Imler, Gregory H., Deschamps, Jeffrey R., Jacobson, Arthur E., Rice, Kenner C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785231/
https://www.ncbi.nlm.nih.gov/pubmed/36557961
http://dx.doi.org/10.3390/molecules27248808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785231/
https://www.ncbi.nlm.nih.gov/pubmed/36557961
http://dx.doi.org/10.3390/molecules27248808

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