Engineering of a Fully Human Anti-MUC-16 Antibody and Evaluation as a PET Imaging Agent

Antibodies that recognize cancer biomarkers, such as MUC16, can be used as vehicles to deliver contrast agents (imaging) or cytotoxic payloads (therapy) to the site of tumors. MUC16 is overexpressed in 80% of epithelial ovarian cancer (EOC) and 65% of pancreatic ductal adenocarcinomas (PDAC), where...

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Detalles Bibliográficos
Autores principales: Babeker, Hanan, Ketchemen, Jessica Pougoue, Annan Sudarsan, Arunkumar, Andrahennadi, Samitha, Tikum, Anjong Florence, Nambisan, Anand Krishnan, Fonge, Humphrey, Uppalapati, Maruti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785263/
https://www.ncbi.nlm.nih.gov/pubmed/36559316
http://dx.doi.org/10.3390/pharmaceutics14122824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785263/
https://www.ncbi.nlm.nih.gov/pubmed/36559316
http://dx.doi.org/10.3390/pharmaceutics14122824

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