Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles during Dissolution

Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a poorly water soluble molecule, with reduced oral b...

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Detalles Bibliográficos
Autores principales: Jara, Miguel O., Warnken, Zachary N., Sahakijpijarn, Sawittree, Thakkar, Rishi, Kulkarni, Vineet R., Christensen, Dale J., Koleng, John J., Williams, Robert O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785291/
https://www.ncbi.nlm.nih.gov/pubmed/36559062
http://dx.doi.org/10.3390/pharmaceutics14122568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785291/
https://www.ncbi.nlm.nih.gov/pubmed/36559062
http://dx.doi.org/10.3390/pharmaceutics14122568

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