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Oral Delivery of Niclosamide as an Amorphous Solid Dispersion That Generates Amorphous Nanoparticles during Dissolution

Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a poorly water soluble molecule, with reduced oral b...

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Detalles Bibliográficos
Autores principales:	Jara, Miguel O., Warnken, Zachary N., Sahakijpijarn, Sawittree, Thakkar, Rishi, Kulkarni, Vineet R., Christensen, Dale J., Koleng, John J., Williams, Robert O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785291/ https://www.ncbi.nlm.nih.gov/pubmed/36559062 http://dx.doi.org/10.3390/pharmaceutics14122568

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