Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion

Von Willebrand Factor (VWF) plays a critical role in thrombus formation, stabilization, and propagation. Previous studies have demonstrated that targeted inhibition of VWF induces thrombolysis when administered in vivo in animal models of ischemic stroke. The study objective was to quantify dose-dep...

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Detalles Bibliográficos
Autores principales: Shea, Susan M., Thomas, Kimberly A., Rassam, Rassam M. G., Mihalko, Emily P., Daniel, Christina, Sullenger, Bruce A., Spinella, Philip C., Nimjee, Shahid M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785393/
https://www.ncbi.nlm.nih.gov/pubmed/36558901
http://dx.doi.org/10.3390/ph15121450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785393/
https://www.ncbi.nlm.nih.gov/pubmed/36558901
http://dx.doi.org/10.3390/ph15121450

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