Microparticle RSV Vaccines Presenting the G Protein CX3C Chemokine Motif in the Context of TLR Signaling Induce Protective Th1 Immune Responses and Prevent Pulmonary Eosinophilia Post-Challenge

Layer-by-layer microparticle (LbL-MP) fabrication was used to produce synthetic vaccines presenting a fusion peptide containing RSV G protein CX3C chemokine motif and a CD8 epitope of the RSV matrix protein 2 (GM2) with or without a covalently linked TLR2 agonist (Pam3.GM2). Immunization of BALB/c m...

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Detalles Bibliográficos
Autores principales: Powell, Thomas J., Jacobs, Andrea, Tang, Jie, Cardenas, Edwin, Palath, Naveen, Daniels, Jennifer, Boyd, James G., Bergeron, Harrison C., Jorquera, Patricia A., Tripp, Ralph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785538/
https://www.ncbi.nlm.nih.gov/pubmed/36560488
http://dx.doi.org/10.3390/vaccines10122078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785538/
https://www.ncbi.nlm.nih.gov/pubmed/36560488
http://dx.doi.org/10.3390/vaccines10122078

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