Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation

Isoform-selective histone deacetylase (HDAC) inhibition is promoted as a rational strategy to develop safer anti-cancer drugs compared to non-selective HDAC inhibitors. Despite this presumed benefit, considerably more non-selective HDAC inhibitors have undergone clinical trials. In this report, we d...

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Detalles Bibliográficos
Autores principales: Ruzic, Dusan, Ellinger, Bernhard, Djokovic, Nemanja, Santibanez, Juan F., Gul, Sheraz, Beljkas, Milan, Djuric, Ana, Ganesan, Arasu, Pavic, Aleksandar, Srdic-Rajic, Tatjana, Petkovic, Milos, Nikolic, Katarina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785542/
https://www.ncbi.nlm.nih.gov/pubmed/36559094
http://dx.doi.org/10.3390/pharmaceutics14122600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785542/
https://www.ncbi.nlm.nih.gov/pubmed/36559094
http://dx.doi.org/10.3390/pharmaceutics14122600

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