Design and Synthesis of Novel Phenylahistin Derivatives Based on Co-Crystal Structures as Potent Microtubule Inhibitors for Anti-Cancer Therapy

Phenylahistin is a naturally occurring marine product with a diketopiperazine structure that can bind to the colchicine site of microtubulin as a possible anticancer agent. To develop more potent microtubule inhibitors, novel phenylahistin derivatives were designed and synthesized based on the co-cr...

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Detalles Bibliográficos
Autores principales: Ding, Zhongpeng, Li, Feifei, Xie, Lianghui, Gu, Minqing, Li, Chunlei, Liu, Chang, Peng, Chao, Li, Wenbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785606/
https://www.ncbi.nlm.nih.gov/pubmed/36547899
http://dx.doi.org/10.3390/md20120752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785606/
https://www.ncbi.nlm.nih.gov/pubmed/36547899
http://dx.doi.org/10.3390/md20120752

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