Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [(11)C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier

[(11)C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are often treated with cytochrome (CYP) modulators which may impact the plasma and brain kinetics of [(11)C]me...

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Detalles Bibliográficos
Autores principales: Breuil, Louise, Ziani, Nora, Leterrier, Sarah, Hugon, Gaëlle, Caillé, Fabien, Bouilleret, Viviane, Truillet, Charles, Goislard, Maud, El Biali, Myriam, Bauer, Martin, Langer, Oliver, Goutal, Sébastien, Tournier, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785688/
https://www.ncbi.nlm.nih.gov/pubmed/36559144
http://dx.doi.org/10.3390/pharmaceutics14122650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785688/
https://www.ncbi.nlm.nih.gov/pubmed/36559144
http://dx.doi.org/10.3390/pharmaceutics14122650

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