Cargando…

Evaluation of the Association between Single Nucleotide Polymorphisms of Metabolizing Enzymes with the Serum Concentration of Paracetamol and Its Metabolites

Intravenous paracetamol is a commonly administered analgesic and antipyretic in inpatient settings. Paracetamol is metabolized by cytochrome P450 (CYP) enzymes followed by conjugating enzymes to mainly glucuronide but to a lesser extent, sulphate metabolites, and oxidative metabolites. Single nucleo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sridharan, Kannan, Qader, Ali Mohamed, Hammad, Mustafa, Jassim, Anfal, Diab, Diab Eltayeb, Abraham, Betsy, Hasan, Hasan M. S. N., Pasha, Sheikh Abdul Azeez, Shah, Shamik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785892/ https://www.ncbi.nlm.nih.gov/pubmed/36557273 http://dx.doi.org/10.3390/metabo12121235

Ejemplares similares

Evaluation of Pharmacogenetics of Drug-Metabolizing Enzymes and Drug Efflux Transporter in Renal Transplants Receiving Immunosuppressants
por: Sridharan, Kannan, et al.
Publicado: (2022)

Efficacy and safety of tocilizumab in critically ill adults with COVID-19 infection in Bahrain: A report of 5 cases
por: ElSeirafi, Mohamed M, et al.
Publicado: (2020)

Drug utilisation in adult, paediatric and neonatal intensive care units, with an emphasis on systemic antimicrobials
por: Sridharan, Kannan, et al.
Publicado: (2021)

Acute kidney injury in critically ill adults: A cross-sectional study
por: ElSeirafi, Mohamed M. A., et al.
Publicado: (2022)

Acute respiratory distress syndrome secondary to COVID-19 mRNA vaccine administration in a pregnant woman: A case report
por: Abraham, Betsy, et al.
Publicado: (2022)

The effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite: paracetamol glucuronide
por: Karbownik, Agnieszka, et al.
Publicado: (2014)

Selective Targeting of Breast Cancer by Tafuramycin A Using SMA-Nanoassemblies
por: El-Deeb, Ibrahim M., et al.
Publicado: (2021)

Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol
por: Tupper, J, et al.
Publicado: (2004)

Comparison of the Analgesic Effect of Paracetamol and Magnesium Sulfate during Surgeries
por: Kalani, Navid, et al.
Publicado: (2016)

Enzyme prodrug therapy: cytotoxic potential of paracetamol turnover with recombinant horseradish peroxidase
por: Humer, Diana, et al.
Publicado: (2021)

Paracetamol versus Paracetamol Plus Ondansetron on Acute Postoperative Pain
por: Aryafar, Mohamad, et al.
Publicado: (2021)

Intravenous paracetamol versus intramuscular pethidine in relief of labour pain in primigravid women
por: Abdollahi, Mohammad-Hasan, et al.
Publicado: (2014)

Analgesic effect of paracetamol monotherapy vs. the combination of paracetamol/parecoxib vs. the combination of pethidine/paracetamol in patients undergoing thyroidectomy
por: Mulita, Francesk, et al.
Publicado: (2021)

AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity
por: Saliba, Soraya Wilke, et al.
Publicado: (2017)

Microbial paracetamol degradation involves a high diversity of novel amidase enzyme candidates
por: Rios-Miguel, Ana B., et al.
Publicado: (2022)

The Role of Hydrogen Bonding in Paracetamol–Solvent and Paracetamol–Hydrogel Matrix Interactions
por: Miotke-Wasilczyk, Marta, et al.
Publicado: (2021)

Investigating Paracetamol’s Role as a Potential Treatment for Parkinson’s Disease: Ab Initio Analysis of Dopamine, l-DOPA, Paracetamol, and NAPQI Interactions with Enzymes Involved in Dopamine Metabolism
por: Harle, Joshua, et al.
Publicado: (2023)

How safe is paracetamol?
por: Star, Kristina, et al.
Publicado: (2015)

The Effects of Paracetamol, Ketorolac, and Paracetamol Plus Morphine on Pain Control after Thyroidectomy
por: Lee, Sun Yeul, et al.
Publicado: (2010)

Correction to: AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity
por: Saliba, Soraya Wilke, et al.
Publicado: (2018)

Development of a Multimatrix UHPLC-MS/MS Method for the Determination of Paracetamol and Its Metabolites in Animal Tissues
por: Pietruk, Konrad, et al.
Publicado: (2021)

Dexamethasone in severe COVID-19 infection: A case series
por: Hassan, Mohamed Eliwa, et al.
Publicado: (2020)

Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol
por: Singhal, Shubha, et al.
Publicado: (2021)

Atrial fibrillation gut syndrome: severe gastroparesis with pyloric spasm following radiofrequency catheter ablation of drug resistant symptomatic atrial fibrillation: a case report
por: Kannan, Lakshmi, et al.
Publicado: (2023)

A Case Series of Uncommon Sodium Disorders in Common Clinical Scenarios
por: Kannan, Lakshmi, et al.
Publicado: (2023)

Acute right atrial and pulmonary artery bone cement mass emboli following vertebroplasty
por: Diab, Mohammad S, et al.
Publicado: (2016)

Paracetamol serum concentrations in preterm infants treated with paracetamol intravenously: a case series
por: van Ganzewinkel, Christ-jan JLM, et al.
Publicado: (2012)

Tolerability to paracetamol and preferential COX-2 inhibitors in patients with cross-reactive nonsteroidal anti-inflammatory drugs hypersensitivity
por: Terzioğlu, Kadriye, et al.
Publicado: (2020)

The effect of preoperative intravenous paracetamol administration on postoperative fever in pediatrics cardiac surgery
por: Abdollahi, Mohammad-Hasan, et al.
Publicado: (2014)

Therapeutic misadventure with paracetamol in children
por: Shivbalan, So, et al.
Publicado: (2010)

The Alzheimer Pandemic: Is Paracetamol to Blame?
por: Jones, Günther Robert Norman
Publicado: (2013)

A study on paracetamol cardiotoxicity
por: Ralapanawa, Udaya, et al.
Publicado: (2016)

Delayed presentation of paracetamol overdose
por: Els, Johnre Retief, et al.
Publicado: (2020)

Paracetamol (Acetaminophen) and the Developing Brain
por: Bührer, Christoph, et al.
Publicado: (2021)

Comparing the effects of ketorolac and Paracetamol on postoperative pain relief after coronary artery bypass graft surgery. A randomized clinical trial
por: Javaherforooshzadeh, Fatemeh, et al.
Publicado: (2020)

Changes in Thyroid Metabolites after Liothyronine Administration: A Secondary Analysis of Two Clinical Trials That Incorporated Pharmacokinetic Data
por: Diab, Nour, et al.
Publicado: (2022)

Population prevalence of high dose paracetamol in dispensed paracetamol/opioid prescription combinations: an observational study
por: Clark, Roderick, et al.
Publicado: (2012)

Randomized comparative trial of efficacy of paracetamol, ibuprofen and paracetamol-ibuprofen combination for treatment of febrile children
por: Vyas, Falgun Indravadan, et al.
Publicado: (2014)

Comparison of paracetamol and diclofenac prescribing preferences for adults in primary care
por: Bayram, Dilara, et al.
Publicado: (2021)

A Systematic Study on the Optimal Nucleotide Analogue Concentration and Rate Limiting Nucleotide of the SARS-CoV-2 RNA-Dependent RNA Polymerase
por: Vatandaslar, Hasan
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_pemnpk5j1guais8hg4n4kdt9bl