Synthesis, Biological Evaluation, and Molecular Dynamics of Carbothioamides Derivatives as Carbonic Anhydrase II and 15-Lipoxygenase Inhibitors

A series of hydrazine-1-carbothioamides derivatives (3a–3j) were synthesized and analyzed for inhibitory potential towards bovine carbonic anhydrase II (b-CA II) and 15-lipoxygenase (15-LOX). Interestingly, four derivatives, 3b, 3d, 3g, and 3j, were found to be selective inhibitors of CA II, while o...

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Detalles Bibliográficos
Autores principales: Channar, Pervaiz Ali, Alharthy, Rima D., Ejaz, Syeda Abida, Saeed, Aamer, Iqbal, Jamshed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785969/
https://www.ncbi.nlm.nih.gov/pubmed/36557863
http://dx.doi.org/10.3390/molecules27248723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785969/
https://www.ncbi.nlm.nih.gov/pubmed/36557863
http://dx.doi.org/10.3390/molecules27248723

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