Silencing of the GluN1-NMDA Glutamate Receptor Subunit by Intranasal siRNA Increases the Latency Time for Seizures in the Pilocarpine Rodent Model of Epilepsy

Temporal lobe epilepsy (TLE) is the most prevalent and treatment-refractory type of epilepsy. Among the different mechanisms associated with epileptogenesis, overstimulation of glutamatergic neurotransmission has been associated with the onset and progression of seizures in TLE. Experimental evidenc...

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Detalles Bibliográficos
Autores principales: Perri, Raphaela Gonçalves Barros, Mantello, Anieli Gaverio, Rosa, Daiane Santos, Beleboni, Renê Oliveira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785971/
https://www.ncbi.nlm.nih.gov/pubmed/36558924
http://dx.doi.org/10.3390/ph15121470

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785971/
https://www.ncbi.nlm.nih.gov/pubmed/36558924
http://dx.doi.org/10.3390/ph15121470

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