Allosteric Inhibition of c-Abl to Induce Unfolded Protein Response and Cell Death in Multiple Myeloma

Endoplasmic reticulum stress activates inositol-requiring enzyme 1α (IRE1α) and protein kinase, R-like endoplasmic reticulum kinase (PERK), the two principal regulators of the unfolded protein response (UPR). In multiple myeloma, adaptive IRE1α signaling is predominantly activated and regulates cell...

Descripción completa

Detalles Bibliográficos
Autores principales: Kosako, Hideki, Yamashita, Yusuke, Morita, Shuhei, Iwabuchi, Sadahiro, Hashimoto, Shinichi, Matsuoka, Taka-Aki, Sonoki, Takashi, Tamura, Shinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786043/
https://www.ncbi.nlm.nih.gov/pubmed/36555805
http://dx.doi.org/10.3390/ijms232416162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786043/
https://www.ncbi.nlm.nih.gov/pubmed/36555805
http://dx.doi.org/10.3390/ijms232416162

Ejemplares similares