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Allosteric Inhibition of c-Abl to Induce Unfolded Protein Response and Cell Death in Multiple Myeloma

Endoplasmic reticulum stress activates inositol-requiring enzyme 1α (IRE1α) and protein kinase, R-like endoplasmic reticulum kinase (PERK), the two principal regulators of the unfolded protein response (UPR). In multiple myeloma, adaptive IRE1α signaling is predominantly activated and regulates cell...

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Detalles Bibliográficos
Autores principales:	Kosako, Hideki, Yamashita, Yusuke, Morita, Shuhei, Iwabuchi, Sadahiro, Hashimoto, Shinichi, Matsuoka, Taka-Aki, Sonoki, Takashi, Tamura, Shinobu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786043/ https://www.ncbi.nlm.nih.gov/pubmed/36555805 http://dx.doi.org/10.3390/ijms232416162

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