Combined Micellar Liquid Chromatography Technique and QSARs Modeling in Predicting the Blood–Brain Barrier Permeation of Heterocyclic Drug-like Compounds

The quantitative structure–activity relationship (QSAR) methodology was used to predict the blood–brain permeability (log BB) for 65 synthetic heterocyclic compounds tested as promising drug candidates. The compounds were characterized by different descriptors: lipophilicity, parachor, polarizabilit...

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Detalles Bibliográficos
Autores principales: Janicka, Małgorzata, Śliwińska, Anna, Sztanke, Małgorzata, Sztanke, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786067/
https://www.ncbi.nlm.nih.gov/pubmed/36555527
http://dx.doi.org/10.3390/ijms232415887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786067/
https://www.ncbi.nlm.nih.gov/pubmed/36555527
http://dx.doi.org/10.3390/ijms232415887

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