Melatonin Mitigates Cisplatin-Induced Ovarian Dysfunction via Altering Steroidogenesis, Inflammation, Apoptosis, Oxidative Stress, and PTEN/PI3K/Akt/mTOR/AMPK Signaling Pathway in Female Rats

Ovarian damage and fertility impairment are major side effects of chemotherapy in pre-menopausal cancer patients. Cisplatin is a widely used chemotherapeutic drug. The present study was designed to assess the ameliorative effects of melatonin as an adjuvant for fertility preservation. Thirty-two adu...

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Detalles Bibliográficos
Autores principales: Al-Shahat, Amal, Hulail, Mohey A. E., Soliman, Nada M. M., Khamis, Tarek, Fericean, Liana Mihaela, Arisha, Ahmed Hamed, Moawad, Rania S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786155/
https://www.ncbi.nlm.nih.gov/pubmed/36559263
http://dx.doi.org/10.3390/pharmaceutics14122769

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786155/
https://www.ncbi.nlm.nih.gov/pubmed/36559263
http://dx.doi.org/10.3390/pharmaceutics14122769

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