Cell-Type-Dependent Role for nsP3 Macrodomain ADP-Ribose Binding and Hydrolase Activity during Chikungunya Virus Infection

Chikungunya virus (CHIKV) causes outbreaks of rash, arthritis, and fever associated with neurologic complications, where astrocytes are preferentially infected. A determinant of virulence is the macrodomain (MD) of nonstructural protein 3 (nsP3), which binds and removes ADP-ribose (ADPr) from ADP-ri...

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Detalles Bibliográficos
Autores principales: Kim, Taewoo, Abraham, Rachy, Pieterse, Lisa, Yeh, Jane X., Griffin, Diane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787352/
https://www.ncbi.nlm.nih.gov/pubmed/36560748
http://dx.doi.org/10.3390/v14122744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787352/
https://www.ncbi.nlm.nih.gov/pubmed/36560748
http://dx.doi.org/10.3390/v14122744

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