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Short-Term Effects of Spirulina Consumption on Glycemic Responses and Blood Pressure in Healthy Young Adults: Results from Two Randomized Clinical Trials

The effects of spirulina consumption added in foods were investigated in two crossover clinical trials (n = 13 different healthy adults). In Trial-1 adults consumed cookies with-and-without spirulina (3.12 g per 100 g final product; 2.5 g spirulina per 50 g available carbohydrates) according to glyc...

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Autores principales: Lympaki, Foteini, Giannoglou, Marianna, Magriplis, Emmanuella, Bothou, Dionysia Lydia, Andreou, Varvara, Dimitriadis, George D., Markou, Giorgos, Zampelas, Antonis, Theodorou, Georgios, Katsaros, George, Papakonstantinou, Emilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787962/
https://www.ncbi.nlm.nih.gov/pubmed/36557218
http://dx.doi.org/10.3390/metabo12121180
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author Lympaki, Foteini
Giannoglou, Marianna
Magriplis, Emmanuella
Bothou, Dionysia Lydia
Andreou, Varvara
Dimitriadis, George D.
Markou, Giorgos
Zampelas, Antonis
Theodorou, Georgios
Katsaros, George
Papakonstantinou, Emilia
author_facet Lympaki, Foteini
Giannoglou, Marianna
Magriplis, Emmanuella
Bothou, Dionysia Lydia
Andreou, Varvara
Dimitriadis, George D.
Markou, Giorgos
Zampelas, Antonis
Theodorou, Georgios
Katsaros, George
Papakonstantinou, Emilia
author_sort Lympaki, Foteini
collection PubMed
description The effects of spirulina consumption added in foods were investigated in two crossover clinical trials (n = 13 different healthy adults). In Trial-1 adults consumed cookies with-and-without spirulina (3.12 g per 100 g final product; 2.5 g spirulina per 50 g available carbohydrates) according to glycemic index (GI) methodology. In Trial-2, adults consumed 4 g, 6 g, and 8 g spirulina as beverage diluted in 50 g D-glucose vs. 50 g plain D-glucose. Capillary blood glucose samples were collected at 0, 15, 30, 45, 60, 90, and 120 min and blood pressure (BP) was measured at beginning and end of each visit in both trials. Trial-1: both cookies with and without spirulina provided medium GI values (59 and 60, respectively, on glucose-scale), but no significant differences were found for BP. Trial-2: both 4 g and 8 g spirulina lowered postprandial glucose at 120 min (95% CI: −1.64 to −16.12 and −1.23 to −15.87, respectively). The results explained 29% of variation. Only 8 g spirulina decreased significantly 90–120 min area under the curve (AUC) for glucose and systolic BP (−4%). No differences were found for fasting glucose. Adding spirulina to cookies did not affect glucose responses and BP. Only 8 g provided significantly lower 90–120 min-AUC for glucose and BP compared to 4 g, 6 g-and-D-glucose, indicating advantages to glycemic control and hypertension.
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spelling pubmed-97879622022-12-24 Short-Term Effects of Spirulina Consumption on Glycemic Responses and Blood Pressure in Healthy Young Adults: Results from Two Randomized Clinical Trials Lympaki, Foteini Giannoglou, Marianna Magriplis, Emmanuella Bothou, Dionysia Lydia Andreou, Varvara Dimitriadis, George D. Markou, Giorgos Zampelas, Antonis Theodorou, Georgios Katsaros, George Papakonstantinou, Emilia Metabolites Article The effects of spirulina consumption added in foods were investigated in two crossover clinical trials (n = 13 different healthy adults). In Trial-1 adults consumed cookies with-and-without spirulina (3.12 g per 100 g final product; 2.5 g spirulina per 50 g available carbohydrates) according to glycemic index (GI) methodology. In Trial-2, adults consumed 4 g, 6 g, and 8 g spirulina as beverage diluted in 50 g D-glucose vs. 50 g plain D-glucose. Capillary blood glucose samples were collected at 0, 15, 30, 45, 60, 90, and 120 min and blood pressure (BP) was measured at beginning and end of each visit in both trials. Trial-1: both cookies with and without spirulina provided medium GI values (59 and 60, respectively, on glucose-scale), but no significant differences were found for BP. Trial-2: both 4 g and 8 g spirulina lowered postprandial glucose at 120 min (95% CI: −1.64 to −16.12 and −1.23 to −15.87, respectively). The results explained 29% of variation. Only 8 g spirulina decreased significantly 90–120 min area under the curve (AUC) for glucose and systolic BP (−4%). No differences were found for fasting glucose. Adding spirulina to cookies did not affect glucose responses and BP. Only 8 g provided significantly lower 90–120 min-AUC for glucose and BP compared to 4 g, 6 g-and-D-glucose, indicating advantages to glycemic control and hypertension. MDPI 2022-11-25 /pmc/articles/PMC9787962/ /pubmed/36557218 http://dx.doi.org/10.3390/metabo12121180 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lympaki, Foteini
Giannoglou, Marianna
Magriplis, Emmanuella
Bothou, Dionysia Lydia
Andreou, Varvara
Dimitriadis, George D.
Markou, Giorgos
Zampelas, Antonis
Theodorou, Georgios
Katsaros, George
Papakonstantinou, Emilia
Short-Term Effects of Spirulina Consumption on Glycemic Responses and Blood Pressure in Healthy Young Adults: Results from Two Randomized Clinical Trials
title Short-Term Effects of Spirulina Consumption on Glycemic Responses and Blood Pressure in Healthy Young Adults: Results from Two Randomized Clinical Trials
title_full Short-Term Effects of Spirulina Consumption on Glycemic Responses and Blood Pressure in Healthy Young Adults: Results from Two Randomized Clinical Trials
title_fullStr Short-Term Effects of Spirulina Consumption on Glycemic Responses and Blood Pressure in Healthy Young Adults: Results from Two Randomized Clinical Trials
title_full_unstemmed Short-Term Effects of Spirulina Consumption on Glycemic Responses and Blood Pressure in Healthy Young Adults: Results from Two Randomized Clinical Trials
title_short Short-Term Effects of Spirulina Consumption on Glycemic Responses and Blood Pressure in Healthy Young Adults: Results from Two Randomized Clinical Trials
title_sort short-term effects of spirulina consumption on glycemic responses and blood pressure in healthy young adults: results from two randomized clinical trials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787962/
https://www.ncbi.nlm.nih.gov/pubmed/36557218
http://dx.doi.org/10.3390/metabo12121180
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