Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance

The genome of cancer cells contains circular extrachromosomal DNA (ecDNA) elements not found in normal cells. Analysis of clinical samples reveal they are common in most cancers and their presence indicates poor prognosis. They often contain enhancers and driver oncogenes that are highly expressed....

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Detalles Bibliográficos
Autores principales: Pecorino, Lauren T., Verhaak, Roel G.W., Henssen, Anton, Mischel, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788557/
https://www.ncbi.nlm.nih.gov/pubmed/36355400
http://dx.doi.org/10.1042/BST20221045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788557/
https://www.ncbi.nlm.nih.gov/pubmed/36355400
http://dx.doi.org/10.1042/BST20221045

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