Identification of ester-linked ubiquitylation sites during TLR7 signalling increases the number of inter-ubiquitin linkages from 8 to 12

The E3 ligase HOIL-1 forms ester bonds in vitro between ubiquitin and serine/threonine residues in proteins. Here, we exploit UbiSite technology to identify serine and threonine residues undergoing HOIL-1 catalysed ubiquitylation in macrophages stimulated with R848, an activator of the TLR7/8 hetero...

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Detalles Bibliográficos
Autores principales: McCrory, Elisha H., Akimov, Vyacheslav, Cohen, Philip, Blagoev, Blagoy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Immunology & Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788571/
https://www.ncbi.nlm.nih.gov/pubmed/36408944
http://dx.doi.org/10.1042/BCJ20220510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788571/
https://www.ncbi.nlm.nih.gov/pubmed/36408944
http://dx.doi.org/10.1042/BCJ20220510

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