Quinoxalinones as A Novel Inhibitor Scaffold for EGFR (L858R/T790M/C797S) Tyrosine Kinase: Molecular Docking, Biological Evaluations, and Computational Insights

Combating acquired drug resistance of EGFR tyrosine kinase (TK) is a great challenge and an urgent necessity in the management of non-small cell lung cancers. The advanced EGFR (L858R/T790M/C797S) triple mutation has been recently reported, and there have been no specific drugs approved for this str...

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Detalles Bibliográficos
Autores principales: Suriya, Utid, Mahalapbutr, Panupong, Wimonsong, Watchara, Yotphan, Sirilata, Choowongkomon, Kiattawee, Rungrotmongkol, Thanyada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788584/
https://www.ncbi.nlm.nih.gov/pubmed/36558033
http://dx.doi.org/10.3390/molecules27248901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788584/
https://www.ncbi.nlm.nih.gov/pubmed/36558033
http://dx.doi.org/10.3390/molecules27248901

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