Calcineurin Inhibitor CN585 Exhibits Off-Target Effects in the Human Fungal Pathogen Aspergillus fumigatus

Calcineurin (CN) is an attractive antifungal target as it is critical for growth, stress response, drug resistance, and virulence in fungal pathogens. The immunosuppressive drugs, tacrolimus (FK506) and cyclosporin A (CsA), are fungistatic and specifically inhibit CN through binding to their respect...

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Detalles Bibliográficos
Autores principales: Juvvadi, Praveen R., Bobay, Benjamin G., Cole, D. Christopher, Awwa, Monaf, Steinbach, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788591/
https://www.ncbi.nlm.nih.gov/pubmed/36547614
http://dx.doi.org/10.3390/jof8121281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788591/
https://www.ncbi.nlm.nih.gov/pubmed/36547614
http://dx.doi.org/10.3390/jof8121281

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