Metabolites of De Novo Purine Synthesis: Metabolic Regulators and Cytotoxic Compounds

Cytotoxicity of de novo purine synthesis (DNPS) metabolites is critical to the pathogenesis of three known and one putative autosomal recessive disorder affecting DNPS. These rare disorders are caused by biallelic mutations in the DNPS genes phosphoribosylformylglycineamidine synthase (PFAS), phosph...

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Detalles Bibliográficos
Autores principales: Souckova, Olga, Skopova, Vaclava, Baresova, Veronika, Sedlak, David, Bleyer, Anthony J., Kmoch, Stanislav, Zikanova, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788633/
https://www.ncbi.nlm.nih.gov/pubmed/36557247
http://dx.doi.org/10.3390/metabo12121210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788633/
https://www.ncbi.nlm.nih.gov/pubmed/36557247
http://dx.doi.org/10.3390/metabo12121210

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