Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD8(+) T cells in giant cell arteritis

OBJECTIVES: Evidence from temporal artery tissue and blood suggests involvement of CD8(+) T cells in the pathogenesis of GCA, but their exact role is poorly understood. Therefore, we performed a comprehensive analysis of circulating and lesional CD8(+) T cells in GCA patients. METHODS: Circulating C...

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Detalles Bibliográficos
Autores principales: Reitsema, Rosanne D, van der Geest, Kornelis S M, Sandovici, Maria, Jiemy, William F, Graver, Jacoba C, Abdulahad, Wayel H, Boots, Annemieke M H, Heeringa, Peter, Brouwer, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788826/
https://www.ncbi.nlm.nih.gov/pubmed/35460236
http://dx.doi.org/10.1093/rheumatology/keac250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9788826/
https://www.ncbi.nlm.nih.gov/pubmed/35460236
http://dx.doi.org/10.1093/rheumatology/keac250

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