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Phenolate‐Induced N−O Bond Formation versus TiemannType Rearrangement for the Synthesis of 3‐Aminobenzisoxazoles and 2‐Aminobenzoxazoles

A novel oxadiazolone‐based method for the synthesis of 3‐aminobenzisoxazoles by N−O bond formation and of 2‐aminobenzoxazoles through a Tiemann‐type rearrangement has been developed. The synthesis of these two pharmaceutically relevant heterocycles was realized by an unexplored retrosynthetic discon...

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Detalles Bibliográficos
Autores principales: Hufnagel, Benedikt, Zhu, W. Felix, Franz, Hanna M., Proschak, Ewgenij, Hernandez‐Olmos, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789021/
https://www.ncbi.nlm.nih.gov/pubmed/36564354
http://dx.doi.org/10.1002/open.202200252