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Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia
Diabetogenic ablation of beta cells in mice triggers a regenerative response whereby surviving beta cells proliferate and euglycemia is regained. Here, we identify and characterize heterogeneity in response to beta cell ablation. Efficient beta cell elimination leading to severe hyperglycemia (>2...
Autores principales: | Furth-Lavi, Judith, Hija, Ayat, Tornovsky-Babeay, Sharona, Mazouz, Adi, Dahan, Tehila, Stolovich-Rain, Miri, Klochendler, Agnes, Dor, Yuval, Avrahami, Dana, Glaser, Benjamin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789023/ https://www.ncbi.nlm.nih.gov/pubmed/36450253 http://dx.doi.org/10.1016/j.celrep.2022.111719 |
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