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Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro

Recent evidence implicates a gut-first pathogenesis in the enteric nervous system (ENS) within a portion of PD patients, yet in vitro investigations have primarily focused on the central nervous system. Here, the preformed fibril (PFF) PD model is applied with co-administered groups of butyrate and...

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Detalles Bibliográficos
Autores principales: Bindas, Adam J., Nichols, Kyla N., Roth, Nicole J., Brady, Ryan, Koppes, Abigail N., Koppes, Ryan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789045/
https://www.ncbi.nlm.nih.gov/pubmed/36564445
http://dx.doi.org/10.1038/s41598-022-26543-x