Cargando…

Aggregation of alpha-synuclein in enteric neurons does not impact function in vitro

Recent evidence implicates a gut-first pathogenesis in the enteric nervous system (ENS) within a portion of PD patients, yet in vitro investigations have primarily focused on the central nervous system. Here, the preformed fibril (PFF) PD model is applied with co-administered groups of butyrate and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bindas, Adam J., Nichols, Kyla N., Roth, Nicole J., Brady, Ryan, Koppes, Abigail N., Koppes, Ryan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789045/ https://www.ncbi.nlm.nih.gov/pubmed/36564445 http://dx.doi.org/10.1038/s41598-022-26543-x

Ejemplares similares

Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes
por: Soucy, Jonathan R., et al.
Publicado: (2019)

Bioengineering the neurovascular niche to study the interaction of neural stem cells and endothelial cells
por: Winkelman, Max A., et al.
Publicado: (2021)

Enteric Nervous System Regulation of Intestinal Stem Cell Differentiation and Epithelial Monolayer Function
por: Puzan, Marissa, et al.
Publicado: (2018)

Engineered bacteria titrate hydrogen sulfide and induce concentration-dependent effects on host in a gut microphysiological system
por: Hayes, Justin A., et al.
Publicado: (2023)

Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein
por: Xu, Ming-ming, et al.
Publicado: (2019)

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine
por: Zhu, Lin-nan, et al.
Publicado: (2018)

Force enhancement in lengthening contractions of cat soleus muscle in situ: transient and steady-state aspects
por: Koppes, Ryan A, et al.
Publicado: (2013)

Alpha-Synuclein Aggregation in Parkinson's Disease
por: Srinivasan, E., et al.
Publicado: (2021)

Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson’s disease
por: Barrenschee, Martina, et al.
Publicado: (2017)

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum
por: Miraglia, Fabiana, et al.
Publicado: (2020)

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro
por: Köppen, Janett, et al.
Publicado: (2020)

Modulation of Alpha-Synuclein Aggregation by Dopamine Analogs
por: Latawiec, Diane, et al.
Publicado: (2010)

Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation
por: Torpey, James H., et al.
Publicado: (2020)

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
por: Elfarrash, Sara, et al.
Publicado: (2019)

Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue
por: Stojkovska, Iva, et al.
Publicado: (2021)

Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein
por: Almandoz-Gil, Leire, et al.
Publicado: (2016)

Claiming control: cooperation with return as a condition for social benefits in Austria and the Netherlands
por: Rosenberger, Sieglinde, et al.
Publicado: (2018)

Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
por: George, Sonia, et al.
Publicado: (2015)

Subcellular localization of alpha-synuclein aggregates and their interaction with membranes
por: Miraglia, Fabiana, et al.
Publicado: (2018)

Alpha-synuclein fragments trigger distinct aggregation pathways
por: Chakroun, Tasnim, et al.
Publicado: (2020)

Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation
por: Rosado-Ramos, Rita, et al.
Publicado: (2021)

Microglial depletion does not impact alpha-synuclein aggregation or nigrostriatal degeneration in the rat preformed fibril model
por: Stoll, Anna C., et al.
Publicado: (2023)

Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson’s disease pathology
por: Ra, Eun A., et al.
Publicado: (2023)

In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129
por: Weston, Leah J., et al.
Publicado: (2021)

Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo
por: Braczynski, Anne K., et al.
Publicado: (2022)

Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of parkinsonism
por: Osterberg, Valerie R., et al.
Publicado: (2015)

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
por: Qiao, Liyan, et al.
Publicado: (2008)

The Small Molecule Alpha-Synuclein Aggregator, FN075, Enhances Alpha-Synuclein Pathology in Subclinical AAV Rat Models
por: Kelly, Rachel, et al.
Publicado: (2021)

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes
por: Domert, Jakob, et al.
Publicado: (2016)

Conformational templating of α-synuclein aggregates in neuronal-glial cultures
por: Sacino, Amanda N, et al.
Publicado: (2013)

Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils
por: Redmann, Matthew, et al.
Publicado: (2017)

Differential Expression of Alpha-Synuclein in Hippocampal Neurons
por: Taguchi, Katsutoshi, et al.
Publicado: (2014)

Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein
por: Elfarrash, Sara, et al.
Publicado: (2021)

Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein
por: Janowska, Maria K., et al.
Publicado: (2015)

Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism
por: Weston, Leah J., et al.
Publicado: (2022)

Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
por: Pan-Montojo, Francisco, et al.
Publicado: (2012)

Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression
por: Bartels, Martin, et al.
Publicado: (2019)

Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity
por: Ysselstein, Daniel, et al.
Publicado: (2017)

Partial Loss of Genomic Imprinting Reveals Important Roles for Kcnq1 and Peg10 Imprinted Domains in Placental Development
por: Koppes, Erik, et al.
Publicado: (2015)

Direct current stimulation enhances neuronal alpha-synuclein degradation in vitro
por: Sala, Gessica, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_62ajs4fg0eamj2t5kicpikrcge