Effects of rifampin on the pharmacokinetics and pharmacodynamics of milvexian, a potent, selective, oral small molecule factor XIa inhibitor

Milvexian (BMS-986177/JNJ-70033093) is a potent, oral small molecule that inhibits the active form of factor XI with high affinity and selectivity. This study assessed the single-dose pharmacokinetic and pharmacodynamic properties of milvexian co-administered with rifampin, an organic anion transpor...

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Detalles Bibliográficos
Autores principales: Perera, Vidya, Wang, Zhaoqing, Lubin, Susan, Christopher, Lisa J., Chen, Wei, Xu, Sophia, Seiffert, Dietmar, DeSouza, Mary, Murthy, Bindu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789074/
https://www.ncbi.nlm.nih.gov/pubmed/36564395
http://dx.doi.org/10.1038/s41598-022-25936-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789074/
https://www.ncbi.nlm.nih.gov/pubmed/36564395
http://dx.doi.org/10.1038/s41598-022-25936-2

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