Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases

The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems was identified. We focused our study on a deep analysis of OXA-48-like-produci...

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Detalles Bibliográficos
Autores principales: Studentova, Vendula, Sudova, Vendula, Bitar, Ibrahim, Paskova, Veronika, Moravec, Jiri, Pompach, Petr, Volny, Michael, Novak, Petr, Hrabak, Jaroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789108/
https://www.ncbi.nlm.nih.gov/pubmed/36564543
http://dx.doi.org/10.1038/s41598-022-26735-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789108/
https://www.ncbi.nlm.nih.gov/pubmed/36564543
http://dx.doi.org/10.1038/s41598-022-26735-5

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