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Preferred β-lactone synthesis can explain high rate of false-negative results in the detection of OXA-48-like carbapenemases
The resistance to carbapenems is usually mediated by enzymes hydrolyzing β-lactam ring. Recently, an alternative way of the modification of the antibiotic, a β-lactone formation by OXA-48-like enzymes, in some carbapenems was identified. We focused our study on a deep analysis of OXA-48-like-produci...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789108/ https://www.ncbi.nlm.nih.gov/pubmed/36564543 http://dx.doi.org/10.1038/s41598-022-26735-5 |