The ULK complex–LRRK1 axis regulates Parkin-mediated mitophagy via Rab7 Ser-72 phosphorylation

Mitophagy, a type of selective autophagy, specifically targets damaged mitochondria. The ULK complex regulates Parkin-mediated mitophagy, but the mechanism through which the ULK complex initiates mitophagosome formation remains unknown. The Rab7 GTPase (herein referring to Rab7a) is a key initiator...

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Detalles Bibliográficos
Autores principales: Fujita, Keitaro, Kedashiro, Shin, Yagi, Takuya, Hisamoto, Naoki, Matsumoto, Kunihiro, Hanafusa, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789397/
https://www.ncbi.nlm.nih.gov/pubmed/36408770
http://dx.doi.org/10.1242/jcs.260395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789397/
https://www.ncbi.nlm.nih.gov/pubmed/36408770
http://dx.doi.org/10.1242/jcs.260395

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