Cargando…

Ts66Yah, a mouse model of Down syndrome with improved construct and face validity

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). The understanding of genotype–phenotype relationships, the identification of driver genes and various proofs of concept for therapeutics have benefited from mouse models. The premier model, named Ts(17(16))65Dn/J (Ts65Dn), displ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duchon, Arnaud, del Mar Muñiz Moreno, Maria, Chevalier, Claire, Nalesso, Valérie, Andre, Philippe, Fructuoso-Castellar, Marta, Mondino, Mary, Po, Chrystelle, Noblet, Vincent, Birling, Marie-Christine, Potier, Marie-Claude, Herault, Yann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789398/ https://www.ncbi.nlm.nih.gov/pubmed/36374158 http://dx.doi.org/10.1242/dmm.049721

Ejemplares similares

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome
por: Duchon, Arnaud, et al.
Publicado: (2011)

Multi-influential genetic interactions alter behaviour and cognition through six main biological cascades in Down syndrome mouse models
por: Duchon, Arnaud, et al.
Publicado: (2021)

Targeting the RHOA pathway improves learning and memory in adult Kctd13 and 16p11.2 deletion mouse models
por: Martin Lorenzo, Sandra, et al.
Publicado: (2021)

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome
por: Duchon, Arnaud, et al.
Publicado: (2016)

Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models
por: Souchet, Benoit, et al.
Publicado: (2019)

The App-Runx1 Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model
por: Raveau, Matthieu, et al.
Publicado: (2012)

Long‐lasting correction of in vivo LTP and cognitive deficits of mice modelling Down syndrome with an α5‐selective GABA(A) inverse agonist
por: Duchon, Arnaud, et al.
Publicado: (2020)

Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome
por: Atas-Ozcan, Helin, et al.
Publicado: (2021)

Deletion of the App-Runx1 region in mice models human partial monosomy 21
por: Arbogast, Thomas, et al.
Publicado: (2015)

Dosage of the Abcg1-U2af1 Region Modifies Locomotor and Cognitive Deficits Observed in the Tc1 Mouse Model of Down Syndrome
por: Marechal, Damien, et al.
Publicado: (2015)

YaHS: yet another Hi-C scaffolding tool
por: Zhou, Chenxi, et al.
Publicado: (2022)

Modeling human disease in rodents by CRISPR/Cas9 genome editing
por: Birling, Marie-Christine, et al.
Publicado: (2017)

Modeling Chromosomes in Mouse to Explore the Function of Genes, Genomic Disorders, and Chromosomal Organization
por: Brault, Véronique, et al.
Publicado: (2006)

Changes in social behavior with MAPK2 and KCTD13/CUL3 pathways alterations in two new outbred rat models for the 16p11.2 syndromes with autism spectrum disorders
por: Martin Lorenzo, Sandra, et al.
Publicado: (2023)

The Human SCN10A(G1662S) Point Mutation Established in Mice Impacts on Mechanical, Heat, and Cool Sensitivity
por: Chidiac, Celeste, et al.
Publicado: (2021)

The Human SCN9A(R185H) Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice
por: Xue, Yaping, et al.
Publicado: (2022)

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models
por: Souchet, Benoit, et al.
Publicado: (2015)

The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome
por: Duchon, Arnaud, et al.
Publicado: (2011)

Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model
por: Braudeau, J., et al.
Publicado: (2011)

Dietary Patterns in Association with Sleep Duration in Iranian Adults: Results from YaHS-TAMYZ and Shahadieh Cohort Studies
por: Mohammadi, Mohammad, et al.
Publicado: (2022)

Cognition and Hippocampal Plasticity in the Mouse Is Altered by Monosomy of a Genomic Region Implicated in Down Syndrome
por: Sahún, Ignasi, et al.
Publicado: (2014)

Reciprocal Effects on Neurocognitive and Metabolic Phenotypes in Mouse Models of 16p11.2 Deletion and Duplication Syndromes
por: Arbogast, Thomas, et al.
Publicado: (2016)

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice
por: Braudeau, J, et al.
Publicado: (2011)

Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO
por: Eletsky, Alexander, et al.
Publicado: (2014)

Controlled Somatic and Germline Copy Number Variation in the Mouse Model
por: Hérault, Yann, et al.
Publicado: (2010)

Pathological trajectory in the Ts65Dn model of Down syndrome
por: Tallino, Savannah, et al.
Publicado: (2023)

DYRK1A, a Novel Determinant of the Methionine-Homocysteine Cycle in Different Mouse Models Overexpressing this Down-Syndrome-Associated Kinase
por: Noll, Christophe, et al.
Publicado: (2009)

The association between dietary patterns derived by three statistical methods and type 2 diabetes risk: YaHS-TAMYZ and Shahedieh cohort studies
por: Beigrezaei, Sara, et al.
Publicado: (2023)

Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development
por: Laffaire, Julien, et al.
Publicado: (2009)

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
por: Nguyen, Thu Lan, et al.
Publicado: (2018)

Cholinergic Senescence in the Ts65Dn Mouse Model for Down Syndrome
por: Kirstein, Martina, et al.
Publicado: (2022)

Breathing and Oxygen Carrying Capacity in Ts65Dn and Down Syndrome
por: DeRuisseau, Lara R, et al.
Publicado: (2023)

Enzymatic and Structural Characterization of rTSγ Provides Insights into the Function of rTSβ
por: Wichelecki, Daniel J., et al.
Publicado: (2014)

Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication
por: Bonnart, Chrystelle, et al.
Publicado: (2012)

Efficient and rapid generation of large genomic variants in rats and mice using CRISMERE
por: Birling, Marie-Christine, et al.
Publicado: (2017)

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
por: Brault, Véronique, et al.
Publicado: (2021)

Gdaphen, R pipeline to identify the most important qualitative and quantitative predictor variables from phenotypic data
por: Muñiz Moreno, Maria del Mar, et al.
Publicado: (2023)

Increased On-Target Rate and Risk of Concatemerization after CRISPR-Enhanced Targeting in ES Cells
por: Erbs, Valérie, et al.
Publicado: (2023)

Increased male reproductive success in Ts65Dn “Down syndrome” mice
por: Moore, Clara S., et al.
Publicado: (2010)

Digastric Muscle Phenotypes of the Ts65Dn Mouse Model of Down Syndrome
por: Glass, Tiffany J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_a8h0saj7k64tb4sm1vsbbeud4q