Bortezomib-induced neurotoxicity in human neurons is the consequence of nicotinamide adenine dinucleotide depletion

The proteosome inhibitor bortezomib has revolutionized the treatment of multiple hematologic malignancies, but in many cases, its efficacy is limited by a dose-dependent peripheral neuropathy. We show that human induced pluripotent stem cell (hiPSC)-derived motor neurons and sensory neurons provide...

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Detalles Bibliográficos
Autores principales: Snavely, Andrew R., Heo, Keungjung, Petrova, Veselina, Ho, Tammy Szu-Yu, Huang, Xuan, Hermawan, Crystal, Kagan, Ruth, Deng, Tao, Singeç, Ilyas, Chen, Long, Barret, Lee B., Woolf, Clifford J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789399/
https://www.ncbi.nlm.nih.gov/pubmed/36398590
http://dx.doi.org/10.1242/dmm.049358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789399/
https://www.ncbi.nlm.nih.gov/pubmed/36398590
http://dx.doi.org/10.1242/dmm.049358

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