Profiling Serum Antibodies Against Muscle Antigens in Facioscapulohumeral Muscular Dystrophy Finds No Disease-Specific Autoantibodies

BACKGROUND: FSHD is caused by specific genetic mutations resulting in activation of the Double Homeobox 4 gene (DUX4). DUX4 targets hundreds of downstream genes eventually leading to muscle atrophy, oxidative stress, abnormal myogenesis, and muscle inflammation. We hypothesized that DUX4-induced abe...

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Detalles Bibliográficos
Autores principales: Greco, Anna, Straasheijm, Kirsten R., Mul, Karlien, van den Heuvel, Anita, van der Maarel, Silvère M., Joosten, Leo A.B., van Engelen, Baziel G.M., Pruijn, Ger J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789485/
https://www.ncbi.nlm.nih.gov/pubmed/34024774
http://dx.doi.org/10.3233/JND-210653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789485/
https://www.ncbi.nlm.nih.gov/pubmed/34024774
http://dx.doi.org/10.3233/JND-210653

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