Messenger RNA in lipid nanoparticles rescues HEK 293 cells from lipid-induced mitochondrial dysfunction as studied by real time pulse chase NMR, RTPC-NMR, spectroscopy

Analytical tools to study cell physiology are critical for optimizing drug-host interactions. Real time pulse chase NMR spectroscopy, RTPC-NMR, was introduced to monitor the kinetics of metabolite production in HEK 293T cells treated with COVID-19 vaccine-like lipid nanoparticles, LNPs, with and wit...

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Detalles Bibliográficos
Autores principales: Sciolino, Nicholas, Reverdatto, Sergey, Premo, Aaron, Breindel, Leonard, Yu, Jianchao, Theophall, Gregory, Burz, David S., Liu, Anna, Sulchek, Todd, Schmidt, Ann Marie, Ramasamy, Ravichandran, Shekhtman, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789524/
https://www.ncbi.nlm.nih.gov/pubmed/36566335
http://dx.doi.org/10.1038/s41598-022-26444-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789524/
https://www.ncbi.nlm.nih.gov/pubmed/36566335
http://dx.doi.org/10.1038/s41598-022-26444-z

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