Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers

Primaquine (PQ) is a racemic drug used in treatment of malaria for six decades. Recent studies suggest that the two enantiomers of PQ are differentially metabolized in animals, and this results in different pharmacological and toxicological profiles. The current study characterizes the pharmacokinet...

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Detalles Bibliográficos
Autores principales: Khan, Washim, Wang, Yan-Hong, Chaurasiya, Narayan D., Nanayakkara, NP Dhammika, Herath, HM Bandara, Harrison, Kerri A., Dale, Gray, Stanford, Donald A., Dahl, Eric P., McChesney, James D., Gul, Waseem, ElSohly, Mahmoud A., Khan, Shabana I., Fasinu, Pius S., Khan, Ikhlas A., Tekwani, Babu L., Walker, Larry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789533/
https://www.ncbi.nlm.nih.gov/pubmed/35709685
http://dx.doi.org/10.1016/j.dmpk.2022.100463

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789533/
https://www.ncbi.nlm.nih.gov/pubmed/35709685
http://dx.doi.org/10.1016/j.dmpk.2022.100463

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