Alfaxalone anaesthesia increases brain derived neurotrophic factor levels and preserves postoperative cognition by activating pregnane-X receptors: an in vitro study and a double blind randomised controlled trial

BACKGROUND: Alfaxalone is a fast acting intravenous anaesthetic with high therapeutic index. It is an analogue of the naturally-occurring neurosteroid allopregnanolone responsible for maintenance of cognition and neuroprotection by activation of brain pregnane X receptors and consequent increased pr...

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Detalles Bibliográficos
Autores principales: Serrao, Juliet M., Goodchild, Colin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789577/
https://www.ncbi.nlm.nih.gov/pubmed/36564723
http://dx.doi.org/10.1186/s12871-022-01940-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789577/
https://www.ncbi.nlm.nih.gov/pubmed/36564723
http://dx.doi.org/10.1186/s12871-022-01940-x

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