The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates

BACKGROUND: Considering the high correlation between the functional decline in Alzheimer’s disease (AD) and the propagation of aggregated tau protein, many research efforts are focused on determining the underlying molecular mechanisms of tau spreading. Heparan sulfate proteoglycans (HSPGs) were rep...

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Detalles Bibliográficos
Autores principales: Ferreira, Andreia, Royaux, Ines, Liu, Jian, Wang, Zhangjie, Su, Guowei, Moechars, Diederik, Callewaert, Nico, De Muynck, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789671/
https://www.ncbi.nlm.nih.gov/pubmed/36564747
http://dx.doi.org/10.1186/s12860-022-00462-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789671/
https://www.ncbi.nlm.nih.gov/pubmed/36564747
http://dx.doi.org/10.1186/s12860-022-00462-1

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