Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival

ABSTRACT: Diffuse large B-cell lymphomas (DLBCL) are broadly dependent on anaplerotic metabolism regulated by mitochondrial SIRT3. Herein we find that translational upregulation of ATF4 is coupled with anaplerotic metabolism in DLBCLs due to nutrient deprivation caused by SIRT3 driving rapid flux of...

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Detalles Bibliográficos
Autores principales: Li, Meng, Teater, Matthew R., Hong, Jun Young, Park, Noel R., Duy, Cihangir, Shen, Hao, Wang, Ling, Chen, Zhengming, Cerchietti, Leandro, Davidson, Shawn M., Lin, Hening, Melnick, Ari M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789686/
https://www.ncbi.nlm.nih.gov/pubmed/35019856
http://dx.doi.org/10.1158/2643-3230.BCD-20-0183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789686/
https://www.ncbi.nlm.nih.gov/pubmed/35019856
http://dx.doi.org/10.1158/2643-3230.BCD-20-0183

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